Should all annotations for a modified
...
nucleotide be included within the sequence listing, or can there be included a reference to a table in the description instead?
The A sequence in a sequence listing should be comprehensive and include all of the necessary annotations so it should not provide details of the modified residue/s in the description onlyfeature keys, qualifiers, and qualifier values to accurately represent the sequence without the need to refer to an external document. It is not acceptable to define a modified nucleotide by referring to a table or paragraph in the patent application description. The sequence listing should not rely on a reference to any external source of information, which includes a for example a table in the description of the patent specification.
...
Otherwise there are modifications which are missing from the resulting sequence listing sequences once it is published as part of the INSDC database, for instance.