With the increased security protocols implemented in Windows 11, users have reported issues with validating sequence listings with the new version of WIPO Sequence. The issue is compounded by various anti-virus software. 

In order to ensure that WIPO Sequence version 3.1.0 and above can run on your Windows 11 operating system, if you have any antivirus software installed (Including Windows Defender), your System Administrator must add these 5 paths to your antivirus exclusions:

1. C:\Users\[YourUsername]\AppData\Local\Programs\WIPO Sequence (or the directory where WIPO Sequence.exe is located)
2. C:\Users\[YourUsername]\AppData\Local\Programs\WIPO Sequence\WIPO Sequence.exe
3. C:\Users\[YourUsername]\AppData\Roaming\wipo_sequence
4. C:\Users\[YourUsername]\AppData\Roaming\wiposequence
5. The folder where you will save your Sequence Listings generated by WIPO Sequence, and/or any folder where you expect to export data coming from WIPO Sequence.

Following this step, please reboot and then WIPO Sequence should be able to validate and generate sequence listings.