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With the increased security protocols implemented in Windows 11, users have reported issues with validating sequence listings with the new version of WIPO Sequence. The issue is compounded by various anti-virus software. 

In order to ensure that WIPO Sequence version 3.1.0 and above can run on your Windows 11 operating system, please ensure that the controlled folder access option is enabled. The Controlled Folder Access is a Windows Security feature designed to protect important files and folders from unauthorized changes by malicious applications, including ransomware. When enabled, it monitors applications that attempt to make changes in files in protected folders and blocks any application which is not on the trusted list. 

In order to enable controlled folder access, follow the steps below while logged in as an administrator:

1. Click Start → Windows Security
2. Go to 'Virus and threat protection' 
3. Click 'Manage ransomware protection' under the 'Ransomware protection' section
4. Turn ON 'Controlled folder access' by toggling the ON switch

After performing these steps, a notification will appear is an application is blocked. You can then allow WIPO Sequence to be a trusted application by selecting 'Allow an app through Controlled folder access'. 

Alternatively, you can use PowerShell:

1. Right-click PowerShell and select 'Run as Administrator' and check that Microsoft Defender Antivirus service is running
2. Copy and past the command below and press Enter:

if you have any antivirus software installed (Including Windows Defender), your System Administrator must add these 5 paths to your antivirus exclusions:

1. C:\Users\[YourUsername]\AppData\Local\Programs\WIPO Sequence (or the directory where WIPO Sequence.exe is located)
2. C:\Users\[YourUsername]\AppData\Local\Programs\WIPO Sequence\WIPO Sequence.exe
3. C:\Users\[YourUsername]\AppData\Roaming\wipo_sequence
4. C:\Users\[YourUsername]\AppData\Roaming\wiposequence
5. The folder where you will save your Sequence Listings generated by WIPO Sequence, and/or any folder where you expect to export data coming from WIPO Sequence.

Following this step, please reboot and then WIPO Sequence should be able to validate and generate sequence listings. # Enable Controlled Folder Access
Set-MpPreference -EnableControlledFolderAccess Enabled